Abstract
Background:Doublecortin domain-containing 2 (DCDC2) is a doublecortin domain-containing gene family member and the doublecortin domain has been demonstrated to bind to tubulin and enhance microtubule polymerization. It has been associated with developmental dyslexia and this protein family member is thought to function in neuronal migration where it may affect the signaling of primary cilia.Objectives:The objective of the study is to find out if there is any association of genetic variants of DCDC2 with developmental dyslexia in Chinese children from Hong Kong.Methods:The dyslexic children were diagnosed as developmental dyslexia (DD) using the Hong Kong Test of Specific Learning Difficulties in Reading and Writing (HKT-SpLD) by the Department of Health, Hong Kong. Saliva specimens were collected and their genotypes of DCDC2 were studied by DNA sequencing or TaqMan Real Time PCR Assays.Results:The most significant marker is rs6940827 which is associated with DD with nominal p-value (0.011). However, this marker did not remain significant after multiple testing corrections and the adjusted p-value from permutation test was 0.1329. Using sliding window haplotype analysis, several haplotypes were found to be nominally associated with DD. The smallest nominal p values was 0.0036 (rs2996452-rs1318700, C-A). However, none of the p values could withstand the multiple testing corrections.Conclusion:Despite early findings that DCDC2 is a strong candidate for developmental dyslexia and that some of the genetic variants have been linked to brain structure and functions, our findings showed that DCDC2 is not strongly associated with dyslexia.
Highlights
The first dyslexia candidate gene DYX1C1 was reported [1] and confirmed by various groups [2], including our1745-0179/17 2017 Bentham OpenGenetic Association With Doublecortin domain-containing 2 (DCDC2) and Developmental DyslexiaClinical Practice & Epidemiology in Mental Health, 2017, Volume 13 105 group [3], and it has been shown to play a molecular role in brain development
Using sliding window haplotype analysis, several haplotypes were found to be nominally associated with developmental dyslexia (DD)
Despite early findings that DCDC2 is a strong candidate for developmental dyslexia and that some of the genetic variants have been linked to brain structure and functions, our findings showed that DCDC2 is not strongly associated with dyslexia
Summary
The first dyslexia candidate gene DYX1C1 was reported [1] and confirmed by various groups [2], including our1745-0179/17 2017 Bentham OpenGenetic Association With DCDC2 and Developmental DyslexiaClinical Practice & Epidemiology in Mental Health, 2017, Volume 13 105 group [3], and it has been shown to play a molecular role in brain development. The first dyslexia candidate gene DYX1C1 was reported [1] and confirmed by various groups [2], including our. Thirteen SNPs showed significant association with at least one of the phenotypes The region of these SNPs clustering contains five genes: VMP, DCDC2, KIAA0319, TTRAP and THEM2. Doublecortin domain-containing 2 (DCDC2) is a doublecortin domain-containing gene family member and the doublecortin domain has been demonstrated to bind to tubulin and enhance microtubule polymerization. It has been associated with developmental dyslexia and this protein family member is thought to function in neuronal migration where it may affect the signaling of primary cilia
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