Abstract
Background and study aim: Egypt has the highest prevalence of hepatitis C virus (HCV) infection in the world and is facing an epidemic of type 2 diabetes mellitus. The objective of this study was to assess the frequency of prediabetes in patients with chronic HCV infection. Subjects and Methods: A cross- sectional study was performed on Session [CurrentTestPartID] HCV patients. Twenty healthy persons were taken as controls. Full history taking, clinical examination, routine laboratory and radiological investigations were done Body mass index (BMI), Waist Hip ratio, serum fasting glucose and fasting insulin were determined. IR was calculated by the Homeostasis Model for Assessment of Insulin Resistance (HOMA-IR), where values less than 2 has been considered completely normal and higher than 2 as a prediabetic state. Results: Serum fasting glucose, fasting insulin and HOMA-IR levels were significantly higher among HCV group compared with control group. The frequency of prediabetic (HOMA-IR values >2) among non-diabetic chronic HCV patients is 63.33%. Conclusion: Chronic HCV patients should be screened regularly for insulin resistance to avoid the double burden of diabetes mellitus and HCV.
Highlights
Hepatitis C virus (HCV) infection is one the main causes of chronic liver disease worldwide
insulin resistance (IR) has a major role in development of type 2 diabetes mellitus (T2DM) and it is the best predictor for the development of T2DM, and it assumes an essential part in development of T2DM [12]
This study showed that there was no significant difference between Child score classification of group II regarding fasting glucose level, fasting insulin and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and this ensured that in this study IR was not connected with the severity of liver disease
Summary
Hepatitis C virus (HCV) infection is one the main causes of chronic liver disease worldwide. Number of studies have demonstrated a strong association between HCV infection and insulin resistance (IR), providing a possible link between this infection and diabetes mellitus [4]. Prediabetes mellitus precedes the development of overt type 2 diabetes mellitus (T2DM). It is associated with increased mortality and morbidity, and fits well with the criteria of a disease condition [5]. The gold standard for the assessment of IR is the euglycemic hyperinsulinemic clamp technique Another more practicable and well-accepted method of measuring systemic IR is the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Egypt has the highest prevalence of hepatitis C virus (HCV) infection in the world and is facing an epidemic of type 2 diabetes mellitus. The objective of this study was to assess the frequency of prediabetes in patients with chronic HCV infection
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