Study of Frequency of High Grade Cervical Intraepithelial Neoplasms (CIN 2, 3) in Patients Infected with Uncommon High Risk Human Papillomavirus

Abstract

Introduction: Despite the significant relationship between human papillomavirus 16 and 18 subtypes and severe cases of cervical cancer, the assessing the frequency of high-grade cervical intraepithelial neoplasms in the patients infected with high-risk human papillomavirus other than 16 and 18 has been less studied in Iranian population. Methods: In this cross-sectional study, the patients referred to Oncology Clinic of Shahid Beheshti Hospital in Isfahan, Iran were selected by positive HPV-typing test through Cobas HPV test and high-risk papilloma virus in 2018 by convenience sampling method. Pap smear was first taken from the patients in the usual way, then they underwent colposcopy, and a biopsy was performed on the lesion during colposcopy. If colposcopy was normal, biopsies were randomly taken from 4 quadrants (12, 3, 9, 6 hours) and, if necessary, endocervical curettage was performed. Samplings were taken by the pathologist of the study center and the prevalence of CIN2 and CIN3 was reported. ANOVA test was performed to compare quantitative variables. Chi-square test was used to compare qualitative variables. SPSS version 17 software was used for statistical analysis of data. Significance level was considered less than 0.05. Results: In this study, 105 individuals with high-risk HPV other than 16 and 18 were evaluated. In the biopsy performed according to the standard diagnostic method, the prevalence of severe form of precancerous lesions (CIN 2, 3) was 9.6% and the most common types of HPV in the patients with CIN 2, 3 were 52 with a frequency of 40% and type 58 with a frequency 30%. Conclusion: Due to the significant prevalence of severe (precancerous) lesions in these patients, it is necessary to review the current protocols.