Study of Formulation Variables Influencing Polymeric Microparticles by Experimental Design

Jitendra B Naik,Rameshwar K Deshmukh

doi:10.5599/admet.2.1.29

Abstract

The objective of this study was to prepare diclofenac sodium loaded microparticles by single emulsion [oil-in-water (o/w)] solvent evaporation method. The 22 experimental design methodology was used to evaluate the effect of two formulation variables on microspheres properties using the Design-Expert® software and evaluated for their particle size, morphology, and encapsulation efficiency and in vitro drug release. The graphical and mathematical analysis of the design showed that the independent variables were a significant effect on the encapsulation efficiency and drug release of microparticles. The low magnitudes of error and significant values of R2 prove the high prognostic ability of the design. The microspheres showed high encapsulation efficiency with an increase in the amount of polymer and decrease in the amount of PVA in the formulation. The particles were found to be spherical with smooth surface. Prolonged drug release and enhancement of encapsulation efficiency of polymeric microparticles can be successfully obtained with an application of experimental design technique.

Highlights

Biodegradable and biocompatible microparticles are popularly investigated drug delivery systems for therapeutic drugs [1,2,3,4,5]
The statistical experimental design is a useful and efficient mathematical approach to evaluate the effect of a factor on a particular response generated by conducting a smaller number of experimental trials
This work shows that diclofenac sodium loaded ethylcellulose polymeric microparticles were successfully prepared

Summary

Introduction

Biodegradable and biocompatible microparticles are popularly investigated drug delivery systems for therapeutic drugs [1,2,3,4,5] They are capable of providing controlled release of the encapsulated drug over a long period of time [6,7]. Solvent evaporation and organic phase separation techniques are widely used in the pharmaceutical industry for the preparation of microparticles [1,2,9,10,11,12]. These microparticles can reduce side effects, enhance the efficacy of therapy, and increase patient compliance

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Results

Conclusion