Abstract
The article is dedicated to the study of polyphenolic compounds in extracts of camel thorn (Alhagi pseudoalhagi). Using UV spectroscopy and HPLC-MS/MS, the composition and content of flavonoids in camel thorn extracts were determined. Characteristic absorption bands for flavonoids were identified through optical spectroscopy. Data on the substance composition in the extract were obtained using the HPLC-MS/MS method. Semi-quantitative analysis of flavonoids was performed using the internal standard addition method with rutin. More than twenty flavonoids were detected in the 70% ethanolic extract. Rhamnetin 3-neohesperidoside and Isorhamnetin 3-neohesperidoside were the major components. The results could be applied in the production of antioxidant pharmaceuticals in the pharmaceutical industry. Comparison of the effects of camel thorn extract with the flavonoid taxifolin showed that the extract is equally effective in preventing early stages of atherosclerosis in the aorta caused by increased angiotensin-converting enzyme activity. At an extract concentration of 0.2%, the activity of the angiotensin converting enzyme in elderly rats and an imals treated with a NO-synthase inhibitor decreases to the values of young control rats.
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