Abstract
Background: Lichen planus (LP) is a mucocutaneous disease that is relatively common between adult populations. LP can present as skin and oral lesions. Objective: The present study aimed to detect the expression of SOCS3 in lichen planus of diseased patients as compared to normal control persons. Patients and methods: This study was a case control study included 30 Lichen planus patients as cases chosen from outpatients attending Dermatology Department at Beni- Suef University Hospital and 30 normal as controls calculated by sample size calculator formula. Results: In our study, LP cases and control were compared using SOCS3; to determine the cut-off value, we performed a ROC analysis. SOCS3 has perfect value for discrimination between LP cases and controls with an area under the ROC curve of 1.0 (95% CI = 0.940 to 1.000, P-value <0.0001). Best cut-off is a value of 1.5 (sensitivity = 100%, specificity = 1.0, J-index = 1.0). Conclusion: Our results were unique in studying the role of SOCS3 in skin form of LP. SOCS3 has perfect value for discrimination between LP cases and controls.
Highlights
Lichen planus is characterized by lichenoid, polygonal papules with fine white lines, named Wickham striae
This study was a case control study included 30 Lichen planus patients as cases chosen from outpatients attending Dermatology Department at BeniSuef University Hospital and 30 normal as controls calculated by sample size calculator formula which is: r: ratio between cases & controls SD: standard deviation from previously published study
In our study we found that expression of of Lichen planus (LP) cases had progressive disease course SOCS3 in lesional skin of LP was significant while (33.3%) had stable disease course
Summary
Lichen planus is characterized by lichenoid, polygonal papules with fine white lines, named Wickham striae. One of the main histopathological features of LP is the keratinocytes vacuolar degeneration in the basal layer. This phenomenon is the result of the action of T helper lymphocytes, T cytotoxic lymphocytes, natural killer cells and dendritic cells that predominate in the inflammatory infiltrate. Objective: The present study aimed to detect the expression of SOCS3 in lichen planus of diseased patients as compared to normal control persons. Results: In our study, LP cases and control were compared using SOCS3; to determine the cut-off value, we performed a ROC analysis. SOCS3 has perfect value for discrimination between LP cases and controls with an area under the ROC curve of 1.0 (95% CI = 0.940 to 1.000, P-value
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