STUDY OF EFFECTS OF INJ. ETOMIDATE IN NORMOTENSIVE AND PIH PATIENTS POSTED FOR LSCS UNDER GENERAL ANAESTHESIA

Abstract

Introduction: In literature there are very few studies regarding use of Etomidate as an inducing agent in patients of PIH and eclampsia. So, we want to study and compare haemodynamic effects of Inj. Etomidate in normotensive and PIH patients at our tertiary hospital. Our aim was to study of effects of Inj. Etomidate in normotensive and PIH patients posted for LSCS under general anaesthesia. Present study was a prospective, comparative & interventional study conducted in department ofMaterial and methods: anaesthesiology of a tertiary care teaching hospital. Study duration was of 2 years (September 2018 to August 2020). Institutional ethical committee approval was taken prior to start of study. All pregnant females belonging to ASA Grade 1-3 undergoing elective or emergency caesarean section under general anaesthesia. Total 60 subjects were recruited & divided into two groups i.e. 30 subjects in each group. Results: In the normotensive group, mean arterial pressure values were signicantly (p < 0.05) higher as compared to start values after scoline , immediately after intubation and at 3 min, 4 min, 20 min, 25 min, 30 min and 45 min values were signicantly reduced. In the hypertension group, mean arterial pressure values at 1 min,2 min, 3 min, 4 min, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min and 45 min were signicantly reduced compared to start values (p<0.001). APGAR score was excellent (7-10) in 27 patients (90%) from normotensive group &in 28 patients (93.33%) from patients with hypertensive disorders of pregnancy group. Etomidate provides a better haemodynamic stability inConclusion: normotensive as well as hypertensive patients posted for LSCS under general anaesthesia. Thus, etomidate can be recommended to use as an induction agent in normotensive as well as hypertensive patients posted for LSCS under general anaesthesia.