Study of Effectiveness of Prophylactic Treatment for Vestibular Migraine Patients

Abstract

Abstract Objectives To evaluate effectiveness of prophylactic drugs in treatment of VM patients. Second to compare between each drug for its efficacy for treatment of VM patients Subjects and Methods Forty-five subjects divided into 3 groups were included in the present study. Group A, 15 subjects received Cinnarzine with mean age of 37.7 years. Group B, 15 subjects received Inderal with mean age of 38.3 years. Group C, 15 subjects received Topamax with mean age of 39 years diagnosed with vestibular migraine. They were subjected to a Dizziness Handicap Inventory questionnaire (DHI), visual analogue scale (VAS), neurological examination, vestibular office tests, videonystagmography (VNG) and sensory organization test (SOT) of computerized dynamic posturography (CDP) before and after receiving treatment according to grouping. Results 3 months after treatment, the mean number of total vertiginous attacks decreased from (14.5 ±9.2) to (7.3 ± 7.8), from (11.5 ±6.6) to (5.2 ± 4.1) and (13.1 ±8.6) to (4.1 ± 3) in Cinnarzine, Propranolol (Inderal) and topiramate (Topamax) groups respectively. DHI scores decreased from (50 ± 12.7) to (34.7± 12.5), (49.7 ± 11.2) to (32.4± 15.6) and (52.7 ±11.2) to (28.3 ± 9.2) in Propranolol (Inderal) and topiramate (Topamax) groups respectively. Conclusions This study provided that all three drugs are effective for ameliorating vertiginous attacks in VM patients; also, the treatment effects were similar in three groups with no significant difference.