Study of effect of 1% sodium hyaluronate application on tympanic membrane perforation

Abstract

<p class="abstract"><strong>Background:</strong> Topical applications of hyaluronic acid have been found to have beneficial effects on closure of tympanic membrane perforations.<strong> </strong>The aim of the study was to evaluate the role of 1% sodium hyaluronate in the repair of small or medium sized dry central tympanic membrane perforation and improvement in hearing following closure of tympanic membrane perforation.</p><p class="abstract"><strong>Methods:</strong> 50 patients with dry central perforation of inflammatory or traumatic origin were taken up. Maximum of 4 applications of 1% sodium hyaluronate were given at weekly intervals. Final mapping for closure of tympanic membrane perforation and hearing assessment was done after 3 months. </p><p class="abstract"><strong>Results:</strong> 26 perforations closed completely while 18 perforations showed significant reduction in size. Thus 44 or 88% perforations showed positive response to 1% sodium hyaluronate application. Hearing Improvement was observed on pure tone audiometry with the average hearing gain in patients after complete closure of tympanic membrane perforation was 12.40 dB with p value of 0.001.</p><p class="abstract"><strong>Conclusions:</strong> Study showed the beneficial effects of 1% sodium hyaluronate application in closure of small and medium size perforations of tympanic membrane perforation and improvement in hearing.</p><p class="abstract"> </p>