Study of early postoperative renal function in the shock wave lithotripsy and retrograde intrarenal surgery

Abstract

Objectives To investigate early postoperative renal function in the shock wave lithotripsy (SWL)and retrograde intrarenal surgery(RIRS). Methods From June 2014 to June 2015, a prospective study was conducted to compare SWL and RIRS in the treatment of renal calculi which were 1.0-1.5cm in diameter. Seventy patients were randomly divided into the observation group (SWL) and the control group(RIRS). Voided urine samples were collected to detect NGAL level before and 2, 6, 12, 24, 48 hours and 1, 2 weeks after SWL and RIRS. Results Mean NGAL levels 6, 12, 24 , 48 hours and 1 week after SWL and RIRS were significantly increased, reached peak at 12 hours, began to decline after 24 hours. Mean NGAL levels were significantly increased post-SWL when compared with baselinehe baseline within 1 week[(5.96±1.5)μg/L vs.(4.84±0.9)μg/L, P=0.0025], and returned to baseline within 2 weeks post-SWL[(5.01±0.8)μg/L vs.(4.84±0.9)μg/L, P=0.346], as well as mean NGAL levels were returned to baseline within 1 weeks post-RIRS[(5.05±0.8)μg/L vs.(4.84±0.9)μg/L, P=0.445]. Mean NGAL levels 6, 12, 24 , 48 hours and 1 week after SWL were significantly increased when compared with post-RIRS(P<0.05). Conclusions SWL and RIRS are both effective on early postoperative renal function. SWL has significantly actute kidney injury when compared with RIRS, and the RIRS time of actute kidney injury recovery is earlier than SWL. Key words: Renal Calculi; Lithotripsy; Ureteroscopes