Abstract
Boron neutron capture therapy (BNCT) is tumor-cell targeted radiotherapy that has significant superiority over conventional radiotherapies. The most neutron beams used for BNCT are from the reactors with high power, new design Miniature Neutron Source Reactor(MNSR) with 45kW with BNCT beam for Suranaree University of Technology(SUT) is being designed and built. According to SUT-MNSR physics design, SUT-MNSR will have the epithermal neutron beam for BNCT treatment. The dose rate distribution in the body should be estimated before SUT-MNSR is used for BNCT clinical trials (Brain tumor). This paper introduces the simulation for SUT-MNSR neutron beam by Monte Carlo N-Particle Transport Code (MCNP), and the establishment of human brain model and physics dose rate distribution in brain tumor by MCNP program.The brain model is established according to the different element in the skin, skull and tissue, the distribution of neutron dose and Gamma dose in the brain model were calculated.
Highlights
Since Japanese scientists treated a patient with head and neck cancer with Boron Neutron Capture Therapy (BNCT) in1960s, so far, some clinical trials used by BNCT have been finished by reactor neutron source
On the bottom of the reactor core, there are two neutron beams which are used for BNCT, one is thermal neutron beam, other is epithermal neutron beam, the neutron spectrum can be shifted by changing the thickness of water
The purpose of this paper is to investigate the dose rate distribution in brain model based on the epithermal neutron beam of SUT-MNSR
Summary
Since Japanese scientists treated a patient with head and neck cancer with BNCT in1960s, so far, some clinical trials used by BNCT have been finished by reactor neutron source. SUT-MNSR is specially designed nuclear reactor and used for Boron Neutron Capture Therapy (BNCT), especially for malignancies and cancers treatment. On the bottom of the reactor core, there are two neutron beams which are used for BNCT, one is thermal neutron beam, other is epithermal neutron beam, the neutron spectrum can be shifted by changing the thickness of water. One beam has two kinds of neutron flux (thermal neutron flux and epithermal neutron flux), two neutron beams are used for the treatment of different kinds of cancer by BNCT, the diameter of beam exit is 12cm. The epithermal neutron beam of SUT-MNSR will be used for brain glioma treatment. The purpose of this paper is to investigate the dose rate distribution in brain model based on the epithermal neutron beam of SUT-MNSR
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