Study of Docosahexaenoic Acid and Eicosapentanoic Acid Effects on Some Biochemical Parameters in Epileptic patients

Abstract

Epilepsy is a worldwide disease characterized by huge changes in several biochemical parameters due to seizure, the main symptoms of the disease. The aim of this study was to assess some biochemical parameters in epileptic patient. This study involves 31 patients with 31 healthy group of apparently healthy subjects as a control group for each one of both groups these parameters were assessed: {8-hydroxydeoxy guanosine (8-OHdG), Malondialdehyde (MDA), Prolactin, Lactate dehydrogenase (LDH), Albumin, Total serum bilirubin (TSB), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine-aminotransferase (ALT) and Creatine phospho kinase (CPK)} in serum of them. 8-OHdG concentrations was increase significantly (P> 0.05) in epileptic patients in compare to control group while MDA show nonsignificant change, the seizure was characterized by increasing of oxidative stress. Situation manifested by its effects, mainly, on nucleic acid. TSB was significantly decreased (P> 0.05) may be due to its function as endogenous antioxidant. albumin did not show any significant difference. CPK has significant increasing (P> 0.05) which be due to the seizure nature, that need high energy production which stimulate the reactions of energy production which lead to upregulate that enzyme. LDH failed to show any significant difference may be due to fast remediation. When comparison the epileptic patients groups during (0, 1 and 2) month of supplementation with EPA and DHA with control subjects. the results were as follow: significantly decrease in 8-HdG concentration level (17.9888±4.30645) ng/ml with (P> 0.05) in 0 month, (14.8998±3.89157) ng/ml with (P> 0.05) in 1 month and (8.5775±2.15075) ng/ml with (P 0.05) in 0 month, (0.4096±0.02873)) ng/ml with (P> 0.05) in 1 month and (0.3983±0.04033) ng/ml with (P <0.05) in 2 month at the comparison with control group (0.6603 ±0.06761) ng/ml while Albumin, GOT, GPT and ALK show non-significant difference in comparison control with the epileptic patients in (0, 1 and 2) month of supplementation with EPA and DHA with control subjects. In CPK, LDH and Prolactin show non-significant difference in comparison control with the epileptic patients in (0, 1 and 2) month of supplementation with EPA and DHA with control subjects.