Abstract
A series of chalcone derivatives ( 1– 4) were studied. The interaction between these ligands and calf thymus DNA was studied with UV–vis spectrophotometry, fluorescence and circular dichroism spectroscopy. The binding constants K were estimated at 0.5–4.6 × 10 5 M −1. All these measurements indicated that the compounds behave as effective DNA-intercalating agents. Electrophoretic separation proved that ligands inhibited topoisomerase I at a concentration of 60 μM.
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