Abstract
Coating protects substances such as L-ascorbic acid from natural processes like oxidation. In this study, L-ascorbic acid was coated by fluid bed technology. A pH-dependent polymer was used as a coating material in order to release L-ascorbic acid (dissolution above pH 5.5) under conditions closest to the skin’s natural condition. Different techniques were used to determine the coating (SEM and size distribution) and to evaluate the percentage of coated L-ascorbic acid and its diffusion through the skin.
Highlights
IntroductionVitamin C (Vit. C) is one of the naturally occurring antioxidants in nature
The morphology of the coating was studied by scanning electron microscopy (SEM)
Vitamin C, is an essential nutrient in the development and repair of tissue, as well as being an antioxidant which slows down the ageing process caused by the damage from free radicals
Summary
Vitamin C (Vit. C) is one of the naturally occurring antioxidants in nature. L-ascorbic acid (LAA) is the chemically active form of Vit. C. Vit. C is found in equal parts as LAA and D-ascorbic acid. C is found in equal parts as LAA and D-ascorbic acid These are essentially isomeric molecules and are mutually interchangeable. Only LAA is biologically active and useful in medical practice. The absorption of Vit. C in the gut is limited by an active transport mechanism and a finite amount of the drug is absorbed despite high oral dosage. Bioavailability of Vit. C in the skin is inadequate when it is administered orally. The use of topical ascorbic acid is favored in the practice of dermatology [1]
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