Abstract
Two sulfonamides of widely different solubilities were incorporated at two concentrations into ointment bases and their diffusion through a membrane into distilled water determined over a 6-hr. period. A lipophilic surfactant appeared to increase the diffusion of sulfacetamide from petrolatum and from the hydrogenated cottonseed oil base. The surfactant increased the diffusion of sulfathiazole from the vegetable oil base but appeared to retard the process when petrolatum was utilized as the base. A reduction of the water–oil ratio in the emulsion bases tended to slow diffusion of both drugs. The results were analyzed statistically using the Student t test.
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