Study of Different Antibiotic Treatment Strategies on Full Term and Late Preterm Newborn Infants With Dyspnea

Abstract

Objective To observe the antibiotic use rate and outcomes of full term and late preterm newborn infants complicated with dyspnea who were managed with two different antibiotics treatment strategies, namely, the clinical risk factors based antibiotic treatment strategy and combination antibiotic treatment strategy that is based on clinical risk factors, infection screening,and monitoring. Methods A cohort study was made with 1 712 newborn infants complicated with dyspnea signs who hospitalized in neonatal ward in West China Second University Hospital,Sichuan University from July 2009 to June 2013. According to hospitalization time periods,they were divided into study group of 776 cases(from July 2011 to June 2013) and control group of 936 cases (from July 2009 to June 2011). The control group adopted the clinical risk factors based antibiotic treatment strategy and the study group received a combination antibiotic treatment strategy based on clinical risk factors, infection screening, and monitoring. Antibiotic use rate, readmission rate, average hospitalization days and infection related adverse events of two groups were statistically analyzed. The age on admission and constituent ratio of gender between two groups had no statistically significant differences(P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital,Sichuan University. Informed consent was obtained from the parents of each participant. Results There were no death case in two groups.①The antibiotic use rate of study group was significantly lower than that of control group, and the difference was statistically significant ( P 0.05).③ There were no statistically significant differences between two groups in incidence rate of infection related adverse events, such as acquired character infection in hospital,bacterial pneumonia, septicemia and necrotizing enterocolitis (P> 0.05). Conclusions The combination antibiotic treatment strategy based on clinical risk factors, infection screening,and monitoring can reduce antibiotic use rate for full term and late preterm newborn infants with dyspnea,and have no harmful effects on them. Key words: [Key words] Anti-bacterial agents; Dyspnea; Infant,newborn