Study of cytomegalovirus infection in renal transplant recipients

Abstract

Background: The purpose of the study was to detect the incidence of active cytomegalovirus (CMV) infection in the population of different immune status and to observe the effect of prophylactic usage of the anti-CMV drug acyclovir. Methods: All patients were divided into post-renal transplantation group (P), fever group (F) and normal group (N). The P group was subdivided into P1 group (less than 6 months) and P2 group (more than 6 months). Results: The incidence of P group was higher than that of N group ( p<0.01), and no significant difference was noted between the incidence of N group and F group ( p>0.05). The average antigen-positive (Ag+) cell number per 5×10 4 leukocytes was 13.5, and 55 in active CMV infection and CMV disease. Conclusions: The result of the study reveals that the incidence of active CMV infection correlates with the population immune status, the small dose of acyclovir in the first 3 months following renal transplantation has prophylactic effect, LSAB method can make rapid and early diagnosis of active CMV infection and CMV disease, the Ag+ number correlates with the severity of infection.