Study of COVID-19 laboratory findings and chest CT findings in assessing disease severity in patients in western Maharashtra

Abstract

Coronavirus disease-19 (COVID-19) has become a world health threat. Early detection of high-risk patients with laboratory and radiological parameters can aid in reducing mortality. Aims and objectives: To assess the clinical, laboratory, radiological parameters in patients with COVID-19 and to compare them with the outcome. The study was conducted in 200 patients presenting with COVID-19 infection in a tertiary care hospital over one month during month of October 2021. Enrolled patients underwent inflammatory markers, haematological markers and CT scan of the thorax on admission. Statistical analysis: Appropriate statistical tests were applied using SPSS software v21 for analysis; p-value<0.05 was considered statistically significant. Mean age of the study population was 51.84(SD±16.02). D-dimer, CRP, ferritin, TLC, NLR, CTSS has shown significant correlation with mortality. Mean CTSS was 9.75 (SD±5.32), mean D-dimer was 0.79 (SD±1.69), mean sr. ferritin was 320.68 (SD±328.04), the mean CRP level was 2.08 (SD±5.86) and mean neutrophil-lymphocyte ratio (NLR) was 5.01 (SD±5.53). The PaO2/FiO2 ratio was identified as an independent risk factor (odd ratio [OR] = 0.992, 95% confidence interval [CI]: 0.986–0.998, p = 0.006). The area under curve of the receiver operator characteristic (AUROC) of PaO2/FiO2 with mortality as outcome was 0.795 (95% CI: 0.684–0.906, p < 0.0001).