Abstract
Study of Correlation between the Paraoxonase 1 (PON1) Activity and Lipid Profile in Various Types of Coronary Heart Disease
Highlights
Correlation diagram No 1, 3, 5, and 7 showed that correlation between Paraoxonase 1 (PON1) vs high-density lipoprotein (HDL)-C was positive in SA (Karl Pearson’s correlation coefficient r = 0.04671), myocardial infarction (MI) (r = 0.2643), and controls (r = 0.06384) and it was negative in unstable angina (UA) (r = −0.098)
Hypercholesterolemia is universally accepted as a major risk factor for atherosclerosis variability regarding lipid profile in the occurrence of cardiovascular events
High-density lipoprotein cholesterol plays an anti-atherogenic role which protects low-density lipoprotein (LDL)-C against oxidative modification which is attributed to the PON1 enzyme located in a subfraction of high-density lipoprotein cholesterol (HDL-C) that contains apoA-1 and clusterin.[15]
Summary
Aim and background: Coronary heart disease (CHD) is the major cause of mortality and morbidity worldwide. Objective: The current study aimed to determine the serum paraoxonase-1 activity and lipid profile with CHD in addition to correlate the relationship between serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL) cholesterol, and paraoxonase-1 level in patients with CHD. There was negative correlation between paraoxonase-1 vs low-density lipoprotein (LDL)-cholesterol in stable angina (r = −0.0291), MI (r = −0.2265), and control group (r = −0.1767), and was positive in UA (r = 6185). Raised blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG)[5,6] were seen in CHD with hypertension. The present study aimed to find PON-1 activity in patients with different types of CHD like stable angina, unstable angina (UA), and myocardial infarction (MI) and compared it with that in healthy controls and tried to find its correlation with lipid variables
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