Study of Comparison of Serum CXCL10 in Vitiligenous Patients before and after NB-UVB

Abstract

Abstract Background Vitiligo is a common, asymptomatic, acquired depigmentation disorder, clinically characterized by milky white sharply demarcated, macules and patches that are scattered symmetrically or asymmetrically over the body causing severe cosmetic distress and social stigma. It can be classified as nonsegmental, segmental, mixed, or unclassified. In vitiligo, melanocytes are targeted by multiple aggressions leading to marked reduction and destruction of pigment cells, including autoimmune process, altered cellular environment, defective melanocytes migration, stress, and genetic factors. Objective To evaluate the serum CXCL10 level in patients with more than one year stability, compare them with healthy controls and compare the serum and tissue level before and after treatment with NB-UVB. Patients and Methods The present prospective controlled study included 20 patients with stable vitiligo (according to the VIDA activity score age of patients ranged from 18 to 54 years old were divided into 10 males and 10 females, and were recruited from the outpatient clinic of dermatology of Ain Shams University Hospital in the period from october 2018 to march 2019, twenty healthy persons were used as controls. All the patients were subjected to a full history taking, general and local clinical examination laboratory tests, and graded via VIDA score as below, digital photography were taken before and after NB-UVB. Results A Total of 20 patients were enrolled in the study, completed the study till the end of follow up of 24 visits during 12 weeks, their ages ranged from 18 to 54years old with a mean of 32.88 ± 10.42 years. Patients were divided into 10 males (50%) and 10 females (50%). Only one patient (5%) had a past medical history of diabetes mellitus and five patients (25%) had similar vitiligo affection in their families. As regard the mean difference of serum CXCL10 in comparison to tissue levels after the treatment there was no statistically significant differences indicating that serum is good indicator for measurement of expression of CXCR3 expression with less invasive procedure and tissue CXCL10 is not necessary to be measured Conclusion Cxcl10 is a useful marker for vitiligo and its severity Serum CXCL10 is equally significant to tissue CXCL10, so serum CXCL10 can replase invasive tissue CXCL10 Some drugs can be directed against CXCL10 or its receptor CXCR3 and may be a useful tool to control vitiligo in the future.