Abstract
In this paper, the reactivity of cobalamin towards S-oxidized cysteine derivatives (sulfenic, sulfinic, sulfonic and S-sulfate) is analyzed and compared to the reactivity towards related nitrogen, oxygen and sulfur-based ligands, focusing on the concept of linkage isomerism. UV-Vis spectra complemented by DFT and TD-DFT calculations show that cysteine and its oxidized derivatives do yield adducts, with a preference for binding to the cobalt through the sulfur.
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