Abstract
Background: Malaria is a major health problem in many parts of India. Several factors have beenattributed to increased morbidity and mortality in malaria with altered hematological andcoagulation parameters. This study was conducted to compare the coagulation parameters ofmalaria cases with those of the healthy carriers. Aims and objectives: To evaluate coagulationabnormalities in patients of malaria and to study the difference in coagulation parameters betweenmalaria patients and healthy controls and to determine the level of significance of the difference.Materials and methodology: This prospective comparative study of 300 patients with laboratorydiagnosed malaria patients (cases) and 300 healthy individuals (controls) was carried out in theDepartment of Pathology in a tertiary care, V. S. General Hospital, Ahmedabad. Result: Comparisonof platelet count, PT, and aPTT between case groups and control groups was statistically significant(p<0.001). Conclusion: There is a significant difference between the platelet count, PT, and aPTTvalues of the two groups. This indicates that in patients with malaria, there is an activation ofintrinsic and extrinsic pathways of coagulation.
Highlights
IntroductionMalaria is a mosquito-borne infectious disease caused by parasitic protozoans of the genus Plasmodium [1]
Materials and MethodologyMalaria is a mosquito-borne infectious disease caused by parasitic protozoans of the genus Plasmodium [1]
There is a significant difference between the platelet count, Prothrombin time (PT), and activated partial thromboplastin time (aPTT) values of the two groups
Summary
Malaria is a mosquito-borne infectious disease caused by parasitic protozoans of the genus Plasmodium [1]. The parasites causing malaria are members of the Haemosporidiae. Several factors have been attributed to increased morbidity and mortality in malaria with altered hematological and coagulation parameters. This study was conducted to compare the coagulation parameters of malaria cases with those of the healthy carriers. Materials and methodology: This prospective comparative study of 300 patients with laboratory diagnosed malaria patients (cases) and 300 healthy individuals (controls) was carried out in the Department of Pathology in a tertiary care, V. Conclusion: There is a significant difference between the platelet count, PT, and aPTT values of the two groups This indicates that in patients with malaria, there is an activation of intrinsic and extrinsic pathways of coagulation
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