Abstract
The CT-complexes of chlorothiazide (n-donor) with picric acid, 3, 5-dinitrobenzoic acid (pi-acceptor) and iodine (sigma-acceptor) were investigated at different temperatures and solvents. These complexes were investigated in polar solvents (methanol, acetonitrile) and nonpolar solvents (dichloromethane and chloroform). The structures of the CT-complexes were studied by 1HNMR, infrared spectra and elemental analyses. The donation method was occurred from the lone pair of electron of nitrogen atom in chlorothiazide to pi- acceptors (n→ π*) and to sigma-acceptor (n–σ). Scanning electronic microscopy (SEM) shows images of chlorothiazide with 3,5-dinitrobenzoic acid, indicates that the produced complex is crystalline with a rod-like shape as the major crystals shapes. The molecular composition of the charge transfers complexes was 1:1 ratio (donor: acceptor) which determined by spectrophotometric titration. The extinction coefficient, eCT, the formation constant, KCT, transition dipole moment (μ), the oscillator strength (f), resonance energy (RN), ionization potential IP and transition energy (ECT) values of the complex were calculated.
Highlights
Donor was obtained from Chemical Industries Development (Syed), Acceptors and solvents were obtained from Sigma-Aldrich Chemical Company
Elemental analyses In Table (1), the values of Elemental analyses were consistent with the photometric data of donor: acceptor (1:1 ratio)
Some of the studied compounds had an effect on some of the tested fungi, Compound CHDNB inhibited the growth of Penicillium corylophilum and Alternaria alternata but they have no effect on Fusarium verticillioides
Summary
Complexes of the chlorothiazide with transition metals were studied (Supuran, 1996). The formation of charge transfer complex of oxatomide as donor with 2, 3-dichloro-5, 6-dicyanobenzoquinone as acceptor was determined spectrophotometric at different temperatures and solvents (Pandeeswaran and Elango, 2006). Studies of complexes formed of colchicine with acceptors were determined in dichloromethane at 21°C (Arslan and Duymus, 2007). Interaction between azelastine and pa-acceptors were synthesized to form charge transfer complexes. The reaction between iodine and drugs (nortriptyline and imipramine) determined spectrophotometric at various temperatures insolvents as chloroform and dichloromethane (Hasani and Akbari, 2007). Spectrophotometric studies were used for the conformation of CT complexes formed between the chlorothiazide and acceptors at different temperatures and solvents.
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