STUDY OF CHANGEMENT OF FIBRINOGEN, HSCRP, VS AND INFARCT VOLUME IN PATIENT WITH ACUTE ISCHEMIC STROKE

Abstract

Objective: To assess the implication of high-sensitivity C-reactive protein(hs-CRP), fibrinogen and erythrocyte sedimentation rate (ESR) in acute stroke and its correlation with the lesion size, vascular risk factors, and neurological impairment. Methods: We included 90 patients consecutively admitted to Department of Neurology, Central hospital of HUE between May 2016 and Dec 2016, with first-ever stroke within the first 72 hours from onset. The fibrinogen, high-sensitivity C-reactive protein, erythrocyte sedimentation rate (ESR) were determined in plasma on admission and after 72 hours. The lesion size was evaluated by CTscan, neurological impairment was evaluated with the NIHSS and the Glasgow Coma Scale. Results: There was a positive correlation between the hs-CRP level and NIHSS, lesion size, fibrinogen, ESR and a negative correlation between the hs-CRP level and Glasgow at both times. There was a positive correlation between fibrinogen level and NIHSS, ESR, hs-CRP and a negative correlation between fibrinogen level and Glasgow after 72 hours. We also found a positive correlation between ESR level and NIHSS, fibrinogen, hs-CRP and a negative correlation between ESR level and Glasgow at both times. After 72 hours, the NIHSS, hs-CRP, fibrinogen levels are independent factors to predict clinical worsening. Conclusion: Inflammatory markers are associated with the acute stroke. The hs-CRP and fibrinogen were higher in patients with clinical worsening compared to those with stable clinical progression. Key words: ischemic stroke, fibrinogen, hsCRP, VSS, pronostic