Abstract
Inflammation is the local reaction of living tissue. The bacterial infections without inflammation would remain un encountered, such kinds of wounds will never heal, the tissues get injured and the organs might be permanently damaged. Detailed investigations have been undertaken on several plants for Anti - inflammatory activity. The most common screening model has been the prevention of Carrageenan induced edema in rats. The pure compounds investigated for Anti - inflammatory activity had diverse chemical structures. Extensive research has been carried out in the membrane permeability, immune stimulant, Hypo cholesterolemic, Anti-inflammatory properties of Saponins. In the plant kingdom large number of biologically active compounds like Saponins glycosides are present. Most of the plants having Saponin glycosides are medicinally important. Many glycosides are used in traditional and modern medicines because of their cardio tonic, analgesic, anti-rheumatic other useful actions. The present study is therefore focussed on discussing the various Ayurvedic medicinal plants having Saponins with Anti- inflammatory action. Method: Classical Ayurvedic texts along with the commentaries and modern literature was collected from Modern books, Journals were carefully studied to compile information about plants containing Saponins and to evaluate with Anti-inflammatory action. It was observed that these Saponin containing plants having different karmas and these karmas having Sotha hara property (Anti-inflammatory activity). Results and conclusion: The below mentioned 10 plants are time tested and mentioned in the classical literature and indicated in many inflammatory disorders with significant rate of success. The study helps to establish a potent drug from the existing formulary.
Highlights
Inflammation is the most common and most important of all disease processes
Inflammation is the local reaction of living tissue
The present study is focussed on discussing the various Ayurvedic medicinal plants having Saponins with Anti- inflammatory action
Summary
Inflammation is the most common and most important of all disease processes. Inflammation is our safeguard against injury (1). The agents that cause the changes in inflammation- the alteration in the blood vessels, the escape of proteins and cells into the tissues, the changes in the tissues- are called the mediators of inflammation (8) They are many active phytochemical constituents of individual plants are insufficient to achieve the desirable therapeutic effects. It causes painful Swelling (inflammation) in the joints of hands, legs, ankle, sacrum, knees where the morbid substance gets seated (28). Anti-inflammatory activity of Saponin may be due to inhibition of the mediators of inflammation such as histamine, serotonin and prostaglandin along with its anti-oxidant property which inhibits the formation of ROS (Reactive oxygen species) which play a major role in inflammation. To collect the information regarding the selected drugs from the Research point of view
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