STUDY OF C-REACTIVE PROTEIN LEVEL IN ACUTE CEREBROVASCULAR ACCIDENTS

Abstract

BACKGROUND Stroke is a major cause of death and physical, mental, psychological morbidity worldwide. According to WHO, about 15 million peoples suffer from stroke each year. C- reactive protein (CRP) is a major acute phase protein in humans. The levels of CRP have been found to be raised in atherothrombotic diseases and related to plaque formation. This study was done to assess the levels of CRP (hs-CRP) in various types of stroke patients, and to predict the severity and prognosis. METHODS Study was conducted in 90 patients admitted in LLR and associated hospitals, G.S.V.M. medical college Kanpur. All patients of stroke fullling the Inclusion and exclusion criteria were enrolled in the study. Serum CRP (hs-CRP) was measured by Turbidimetric immunoassay. Statistical analysis was done by using T test and chi square test. Our patients were mostly in the age group of 40-79 RESULTS years with mean age 59 year. Patients were mostly males. hsCRP levels were found to be raised statistically signicant in all types of stroke patients as compared to controls. There was signicant rise from rst day to third day (P<0.05). CRP was maximum in patients of cerebral infarction as compared to other types of stroke. Mean CRP of expired patients was higher as compared to whole study group (P<0.05). CONCLUSIONS We concluded that hsCRP level elevation is common in stroke patients and its evaluation could be an important prognostic parameter in stroke patients