Abstract
The aim. To study in experiment the effect of bone marrow aspirate injection on the course of denervation-reinnervation processes in skeletal muscle using neurophysiological research method. Materials and methods. Experimental study was performed on 36 mature rabbits weighing 3-4 kg. Experimental model of the peripheral nerve acute injury and neurorrhaphy is taken as a basis. Animals were divided into 4 groups of 9 animals per group (3 animals for each experimental period). At 8, 12, and 16 weeks after surgery, all rabbits underwent needle EMG of the target muscles (m. gastrocnemius, and m. tibialis anterior) to study denervation-reinnervation changes. Results. Results of target muscles electromyographic examination are shown. As norm, we took motor unit potentials parameters, which were registered during the study of contralateral (not operated) pelvic limbs. Largest number of registered MUPs at different stages of the denervation-reinnervation process was observed, and was significantly higher (α = 0.07) in the groups in which bone marrow aspirate was injected in relation to group without bone marrow aspirate injection. Changes in the parameters of the registered MUPs in all groups corresponded to the general characteristics of the denervation-reinnervation process. Conclusions. Injection of bone marrow aspirate into the target muscles during surgery and in the early stages of reinnervation (in experimental study it is 7 weeks after surgery) – reliably (α = 0.07) promotes improvement of reinnervation processes in muscles, which is manifested by registration of more motor unit potentials.
Highlights
In general structure of injuries – 1.3–2.8 % are traumatic lesions of peripheral nerves of the extremities [1]
The aim of the research was to study in experiment the effect of bone marrow aspirate injection on the course of denervation-reinnervation processes in skeletal muscle using neuro physiological research method
We took motor unit potentials (MUPs) parameters, which were registered during the study of contralateral pelvic limbs
Summary
In general structure of injuries – 1.3–2.8 % are traumatic lesions of peripheral nerves of the extremities [1]. In structure of peripheral nerves injuries of the extremities – 77 % belong to the upper extremity [3]. Ovais et al analyzing long-term results (27 months) of 75 cases of acute peripheral nerves microsurgical restoration indicate that: excellent results were achieved in 50 % of patients, good – 37.5 %, and (2020), «EUREKA: Health Sciences» Number 6 satisfactory – 12.5 % [6]. A. Ruijs in 2005 conducted a meta-analysis on the results of microsurgical reconstruction of peripheral nerves, and showed that satisfactory results of functional recovery were achieved in only 51.6 % of patients [7]
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