Abstract
Introduction. Biologically active compounds 4,6-dinitro-5,7-dichlorobenzofuroxan (4,6-DNDHBFO) and 5-nitro-4,6-dichlorobenzofuroxan (5-NDHBFO) effectively in-hibit ultra-resistant microorganisms: Staphylococcus aureus, pathogenic fungi – Aspergillius niger, Coniophora cerebella, Candida albicanas and other microor-ganisms. Mixed systems based on 4,6-DNDHBFO and 5-NDHBFO exhibit high potentiated synergistic activity against Aspergillius niger. Currently, there are no full-fledged studies about the mechanism of synergism of 5-NDHBFO and 4,6-DNDHBFO in a solidphase system. The results of the study of solid-phase sys-tems 5-NDHBFO – 4,6-DNDHBFO by IR spectroscopy will make it possible to establish the nature of the interaction between the components of the binary mix-ture.Aim. Experimental study of the intermolecular interaction of 5-NDHBFO with 4,6-DNDHBFO by the IR spectroscopy method.Materials and methods. The intermolecular interaction of 5-NDHBFO with 4,6-DNDHBFO at different ratios in a solid-phase system was studied by the IR spectroscopy method.Results and discussion. Based on the results of the study, the physico-chemical interaction of 5-NDHBPO with 4,6-DNDHBFO in solid-phase systems was revealed. Shifts and changes in the intensities of the characteristic frequencies of functional groups involved in the formation of intermolecular bonds between 5-NDHBPO and 4,6-DNDHBPO were revealed.Conclusion. The nature of the interaction between 4,6-DNDHBFO and 5-NDHBFO in the solid-phase system was established, leading to the appearance of a synergy effect. The interaction of 5-NDHBFO with 4,6-DNDHBFO in a bi-nary system is due to the formation of an intermolecular hydrogen bond. The in-teraction involves the proton of the 5-NDHBFO molecule, the oxygen of the fu-roxan ring of 4,6-DNDHBFO, as well as the halogen atom of 4,6-DNDHBFO at an equimolar ratio of the components of the solid-phase system.
Highlights
Active compounds 4,6-dinitro-5,7-dichlorobenzofuroxan (4,6-DNDHBFO) and 5-nitro-4,6-dichlorobenzofuroxan (5-NDHBFO) effectively in-hibit ultra-resistant microorganisms: Staphylococcus aureus, pathogenic fungi – Aspergillius niger, Coniophora cerebella, Candida albicanas and other microor-ganisms
The results of the study of solid-phase sys-tems 5-NDHBFO – 4,6-DNDHBFO by IR spectroscopy will make it possible to establish the nature of the interaction between the components of the binary mix-ture
The intermolecular interaction of 5-NDHBFO with 4,6-DNDHBFO at different ratios in a solid-phase system was studied by the IR spectroscopy method
Summary
В качестве объекта исследования рассматривали двухкомпонентную систему «5-НДХБФО – 4,6-ДНДХБФО» переменного состава. Индивидуальные соединения 4,6-ДНДХБФО и 5-НДХБФО были синтезированы по известным методикам [14]. Системы готовили из индивидуальных компонентов 5-НДХБФО и 4,6-ДНДХБФО, которые взвешивали на аналитических весах высокого класса точности по ГОСТ 24104-2001 (точность взвешивания ±0,0001 г). Смеси для ИК-спектроскопии готовили путем мокрого смешивания, предварительно рассчитанных количеств индивидуальных компонентов в фарфоровых ступках в среде четыреххлористого углерода Масса смесей после испарения растворителя составила 0,5000 г. Исследования ИК-спектров были проведены для смесей 5-НДХБФО – 4,6-ДНДХБФО состава 90:10, 50:50 и 10:90 (%, вес.) соответственно. ИК-спектры аналитических образцов в области 4000–400 см-1 регистрировали на ИК-Фурье спектрометре Bruker Vector-22 (Германия) при комнатной температуре в виде суспензии в вазелиновом масле (CAS 8012-95-1, Panreac). Интерпретацию полученных ИК-спектров проводили с применением данных [15, 16]
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