Study of biocompatibility in ceramic coating doped with NaF on Ti-3Zr-2Sn-3Mo-25Nb by micro-arc oxidation

Abstract

ABSTRACT The surface of titanium and titanium alloys can easily form a Ti-OH bond by absorbing water to induce apatite nucleation, and shows good biological activity and osseointegration ability, which is especially suitable for bone implantation. In this study, a calcium-phosphorus-containing ceramic coating was prepared on a non-toxic titanium alloy -Ti-3Zr-2Sn-3Mo-25Nb (TLM) – by using micro-arc oxidation treatment, accompanied by doping NaF as additive. Micro-morphology, phase composition, pH value, contact angle and clotting time were analysed to study the influence of NaF concentration (1.0–5.0 g L−1) on the biocompatibility performance of the coating in a simulated human body fluid (SBF) immersion experiment. The results showed that, adding an appropriate amount of NaF is beneficial to improving the biocompatibility of the coating, but as the concentration of NaF increases, the biocompatibility of the coating first increases and then decreases. When the NaF addition amount is 3.0 g L−1, the coating has the best wettability and anticoagulant properties.