Abstract
The biochemical effects of anti-inflammatory drugs, hydrocortisone, phenylbutazone and indomethacin in carrageenin oedema and cotton pellet granuloma have been compared in male albino rats. In carrageenin oedema, the drugs had no effect upon ATPase activities of liver, brain or oedema tissue. In cotton pellet granuloma, the drugs significantly increased ATPase activity of granuloma tissue but not the activities of liver and brain. The ATPase activities of liver and brain remained unaltered during carrageenin oedema as well as cotton pellet granuloma. The activities of liver transaminases, glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) increased more significantly in carrageenin oedema than in cotton pellet granuloma. Hydrocortisone, phenylbutazone and indomethacin significantly inhibited both GPT and GOT activities in liver in carrageenin oedema and cotton pellet granuloma. The drugs also inhibited liver GPT in normal rats. The significance of these biochemical effects is discussed in relation to the pharmacological activities of the drugs.
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