Study of association between different microRNA variants and the risk of idiopathic recurrent pregnancy loss

Abstract

Recurrent pregnancy loss (RPL) is a common reproductive disorder among women and a major cause of infertility among them; however, the underlying causes of RPL remain unknown which have led to great difficulties and complications in the treatment. MicroRNAs (miRNA) have been shown to be a potential diagnosis tools in different reproductive disorders. This study aimed to investigate the association of four different miRNA variants with the risk of idiopathic RPL (iRPL). A total of 450 women including 225 patients and 225 controls were recruited in this study. DNA was extracted, and genotyped by PCR method. Haplotype analysis, as well as linkage disequilibrium between SNPs, was performed. This study suggested that rs4636297, rs41291957, and rs353292, but not rs531564 can play a risk factor role for iRLP.