Abstract
Reactive oxygen species (ROS) are generated due to severe oxidative stress, thereby resulting in pathogenesis of various disorders in humans, including psoriasis. DNA damage is the major manifestation of long term ROS exposure. ROS can be scavenged by natural antioxidant compounds present in medicinal plants. In this study, aqueous, methanolic and chloroform extracts of eleven dermatologically significant Indian medicinal plants were evaluated for their ROS scavenging and antioxidant properties, using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, Trolox equivalent antioxidant capacity (TEAC), Ferric reducing antioxidant power assay (FRAP), along with total phenolic content determination. Lipoxygenase inhibition assay was conducted to determine anti-inflammatory activities. DNA-damage protective capacities were also assessed using plasmid pBluescript II SK(–) DNA, where DNA damage was induced by Fenton reaction. The study reveals that the extracts of T. cordifolia, C. paniculatus, C. longa and A. vera performed far much better, in almost all the assays, with regards to P. corylifolia, a medicinal plant traditionally used to treat psoriasis, thus indicating these plants to be potent sources of effective drug formulation for treatment of psoriasis.Int. J. Appl. Sci. Biotechnol. Vol 5(2): 141-149
Highlights
The outermost covering of the whole body, is prone to a lot of oxidative stresses leading to elevated production of unstable molecules known as reactive oxygen species (ROS), such as O2, H2O2 and OH, which are highly toxic to the cells of human body
LOXs are enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acid (PUFA) like Arachidonic acid (AA) to form specific unsaturated fatty acid hydroperoxide derivatives (Brash, 1999)
This study provides an insight into the possible role of some of the selected medicinal plants in the treatment of psoriasis
Summary
The outermost covering of the whole body, is prone to a lot of oxidative stresses leading to elevated production of unstable molecules known as reactive oxygen species (ROS), such as O2–, H2O2 and OH, which are highly toxic to the cells of human body. They induce numerous lesions in DNA by causing deletions, mutations and other lethal genetic effects, severely damaging it (Mittova, 2000) Another important factor that contributes towards the exacerbation of psoriasis is the inflammatory action of Lipoxygenases (LOXs) present in the body. LOXs are enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acid (PUFA) like Arachidonic acid (AA) to form specific unsaturated fatty acid hydroperoxide derivatives (Brash, 1999) These LOX products have been reported to have an implication in psoriasis and have been found to be present in psoriatic lesions (Hammarstrom, 1975; Camp, 1983). Eleven medicinal plants with beneficial dermatological properties were screened for their antioxidative, free radical scavenging, and anti-inflammatory properties, along with total phenolic content determination of their aqueous, methanolic, and chloroform extracts. This study provides an insight into the possible role of some of the selected medicinal plants in the treatment of psoriasis
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