Abstract
<p class="Abstract">The aim of this study was to investigate the antidepressant effects of grape seed oil in male mice (n=60) using tail suspension and forced swim tests. Mice were divided to six groups of 10 in each group. Group I: Intraperitoneally receiving normal saline; Group II: Received normal saline &amp; stress; Group III-V: Injected (i.p.) with different (60, 120, and 240 mg/kg) doses of grape seed oil; and Group VI: Received fluoxetine (10 mg/kg). Grape seed oil in 60 mg/kg significantly decreased immobility time in tail suspension and forced swim tests under chronic unpredictable stress compared to groups under chronic stress receiving normal saline and grape seed oil (120 and 240 mg/kg). Grape seed oil (60 mg/kg) significantly improved the motor balance in mice under chronic stress. It had no significant effect on serum corticosterone level. Grape seed oil can improve depression symptoms in mice.</p><p><strong>Video Clip of Methodology</strong>:</p><p>0 min 14 sec <a href="https://youtube.com/v/7JgyR4mTUOw">Full Screen</a> <a href="https://youtube.com/watch?v=7JgyR4mTUOw">Alternate</a></p>
Highlights
Depression is a multifactorial, chronic, and life-threatening disorder with high prevalence rate worldwide
There was no significant difference in immobility time between the groups under stress receiving normal saline and those injected with grape seed oil (120 and 240 mg/kg) (p
Intraperitoneal injection of grape seed oil (60 mg/kg) significantly decreased immobility time compared to normal saline and grape seed oil (120 and 240 mg/kg) in the mice under stress (p
Summary
Depression is a multifactorial, chronic, and life-threatening disorder with high prevalence rate worldwide. People with major depression have been reported to have different levels of oxidative stress and decrease in antioxidant enzymes (Sarandol et al, 2007). Studies have indicated that some antidepressants can reduce certain oxidative stress markers and cause increase in internal antioxidants. There are almost 30 different types of antidepressants. These drugs cause certain adverse effects due to their effects on various neuromediators. Now-a-days, researchers are considering natural, plant-based compounds due to numerous adverse effects of chemical antidepressants (Rabiei and Rabiei, 2017; Aslam and Sultana, 2015)
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