Study of Anticancer Drug 3'-Deoxyadenosine Adsorption of Nano Zn-based Zeolitic Imidazolate Framework

Abstract

In this research, a zinc-based zeolitic imidazolate framework (Zn-ZIF) nanomaterial was successfully synthesized and investigated for adsorption of 3'-deoxyadenosine as an anticancer drug. The nano MOF was prepared via a mild reaction of zinc acetate dihydrate and benzimidazole as organic bridges in a solvent mixture of methanol, toluene, and ammonium hydroxide. The structure and properties of the synthesized nanomaterial characterized by modern physical analysis techniques such as X-ray diffraction (P-XRD), thermogravimetric analysis (TGA), infrared spectroscopy (FT-IR), and N2 isotherm adsorption at 77 K. The analyzing results show that the material has high crystallinity, thermal stability up to 300 oC, and surface area approximately 700 m2 g-1. In the experiments for adsorption of anticancer drug 3'-deoxyadenosine, various parameters of adsorption process were investigated including solvent (dimethyl sulfoxide, ethanol, and deionized water) and drug concentrations in range of 0.1-1.0 mg mL-1. Moreover, the drug-loaded MOF nanosystems were characterized by P-XRD technique to study their stability after adsorption process. The resuls of drug adsorption experiments indicated that the maximum adsorption capacity of 3'-deoxyadenosine of the nanomaterial was approximately 190 mg g-1 after 24 h in dimethyl sulfoxide and the adsorption efficiency was about 37%. The study dislays that the Zn-ZIF nanomaterial has high potential as a nanocarrier to deliver 3'-deoxyadenosine in cancer treatment.