Abstract
The present study was designed to evaluate the effects of sodium metavanadate against experimentally-induced gastric ulcers. In an attempt to establish the antiulcer effect and its mechanism of action, sodium metavanadate (3, 5 mg/kg, i.p.) was studied in ethanol and pylorus ligation-induced gastric ulcer models. Sodium metavanadate significantly reduced ulcer index in both the ulcer models. Besides it showed significant reduction in total acid out put along with significant rise in total carbohydrates and mucin activity in gastric juice in pylorus ligation model. Therefore, it is suggested that sodium metavanadate possesses significant antiulcer activity. The probable mechanisms for its antiulcer effect can be attributed to decrease in acid secretion and increase in mucoprotective substances.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
