Abstract
The current study was intended to assess the antidepressant action of Successive extraction of Petroleum ether (PEETP), Chloroform (CHETP), ethylacetate (EAETP), Ethanolic (EETP) & Aqueous (AETP) extracts of Tridax procumbens (TP)by Tail suspension test (TST). The 25-30g over night fasted mice were selected and divided into six groups. Dose was fixed as per OECD 425 Guidelines acute toxicity studies. Extracts and standard were administered 1 hr prior to study,time period and percentage diminution of immobility were noted. The CETP & EAETP 200 mg/kg extracts shows significant (p<0.01) reduction of immobility time was observed when compared to control. Both EETP 200 mg/kg effect and escitalopram (10mg/kg) shows the more significant (P<0.001) when compared to negative control. AETP was shows p˂0.05 significant whereas PEETP no significant to negative control, the studies result recommends that ethanol extract pronouncedantidepressant effect. It may be the presences of Phtoconstituents attribute the level of Neurotransmitter like 5 hydroxy tryptamine and noradrenaline.
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