Abstract
Antitumor Hybrid BT009K Modulates Inflammation Induced Neovascuaralization in Both Tumorigenic and Non-Tumorigenic Model SystemShamanth Neralagundi H.G., Zabiulla, Shaukath Ara Khanum, Manjunatha H., Prabhakar B.T.
Highlights
The concept of angiogenesis, or neovascularization, is established as the formation of new capillaries from pre-existing capillaries and venules (Bischoff, 1995)
BALB/c mice were used as a model; under anesthesia, the mice had a sponge of 0.5 x 0.5 cm introduced into their dorsal subcutaneous tissue; they were divided into 4 groups and daily gavage treated: 1) control group (n=13) – treated with 0.3 mL of saline solution; 2) aminophylline group (n=16) – 50 mg/kg; 3) roflumilast group (n=14) – 5mg/kg; 3) sildenafil group (n=12) –100 mg/kg
According to the results obtained, we concluded that aminophylline, roflumilast and sildenafil did not cause any alteration in the angiogenesis evaluated by the sponge-implantation method
Summary
The concept of angiogenesis, or neovascularization, is established as the formation of new capillaries from pre-existing capillaries and venules (Bischoff, 1995) It plays an important role in many physiological processes. Like vascular endothelial cells (VEC) which are present in all vessels of the body forming the most part of capillary structures, are necessary to make this process occur. Under stimulus, they migrate and trigger the neovascularization activity. Adenylate cyclase and guanylate cyclase are enzymes that catalyze the AMP transformations into cAMP and cGMP respectively These second messengers play an important role in the migration of many cells like endothelial cells (Ghosh et al, 2010). This study aimed to analyze the effects of phosphodiesterase inhibition on angiogenesis
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