Abstract
Objective: to study the level of angiogenesis factors (fibroblast growth factor, platelet growth factor, endostatin), as well as tumor necrosis factor alpha in the acute period of myocardial infarction 6 months after the event, depending on the presence of drug revascularization.Materials and methods: patients with AMI of the anterior wall of the left ventricle with St segment elevation were Included. AMI patients were divided into groups: I group included patients who received thrombolytic therapy (TLT), II - patients who did not receive TLT. Group III was composed of relatively healthy volunteers. Angiogenesis indicators were studied depending on the TIMI scale and complications at the hospital and outpatient stages of treatment.Results: In AMI patients, an increase in angiogenesis processes was detected, regardless of the presence or absence of thrombolytic therapy, and an increase in the level of angiogenesis inducers. Six months after the activity of angiogenesis processes is maintained, while inflammation decreases − a decrease in the tumor necrosis factor alpha.Conclusions: In patients with AMI with ST segment rise in the acute period, there is an increase in angiogenesis processes, regardless of the presence or absence of TLT.
Highlights
Objective: to study the level of angiogenesis factors, as well as tumor necrosis factor alpha in the acute period of myocardial infarction 6 months after the event, depending on the presence of drug revascularization
AMI patients were divided into groups: I group included patients who received thrombolytic therapy (TLT), II - patients who did not receive TLT
Angiogenesis indicators were studied depending on the TIMI scale and complications at the hospital and outpatient stages of treatment
Summary
ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России, Ростов-на-Дону, Россия. Цель: изучить в остром периоде инфаркта миокарда и через 6 месяцев после события в зависимости от наличия медикаментозной реваскуляризации уровень ангиогенных и провоспалительных факторов. Материалы и методы: в исследование включены пациенты с острым инфарктом миокарда (ОИМ) с подъемом сегмента ST. Больные ОИМ были разделены на группы: в I группу вошли пациенты, которым была проведена тромболитическая терапия (ТЛТ), во II — пациенты, которым ТЛТ не проводилась. Результаты: независимо от проведения ТЛТ и восстановления коронарного кровотока у пациентов с ОИМ выявлено усиление процессов ангиогенеза, проявляющееся в повышение уровня факторов, стимулирующих ангиогенез. Через шесть месяцев отмечается сохранение активности процессов ангиогенеза, при этом уменьшается воспаление (снижение фактора некроза опухоли альфа). Выводы: у пациентов с ОИМ с подъемом сегмента ST в остром периоде наблюдается усиление процессов ангиогенеза, независимо от наличия или отсутствия проведения ТЛТ. Изучение факторов ангиогенеза у пациентов с острым инфарктом миокарда.
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