STUDY OF ANAEMIA & IRON PROFILE IN CHRONIC KIDNEY DISEASE (CKD) PATIENTS ON MAINTENANCE DIALYSIS AND ITS CORRELATION WITH DIABETES MELLITUS

Abstract

Most patients with chronic kidney disease (CKD) have anaemia, the cause of which is erythropoietin and iron deciency. Anaemia in patients on haemodialysis is associated with poor patient outcomes. Diabetes remains one of the predominant aetiologies of CKD all over the world. The study was undertaken to study the iron prole in haemodialyzed patients and its corelation with diabetes mellitus. Sixty-six patients were enrolled in the study with the aim to study the prevalence of anaemia and diabetes in haemodialyzed patients as well as the iron prole in these patients. Patients were studied as a single group as well as divided into two groups, a non-diabetic group comprising of 36 patients and a diabetic group comprising of 30 patients. Anaemia was found to be prevalent in 56(84.84%) patients out of which 28(50%) were diabetics. Also, diabetics comprised of 45.45% of the study group. Various parameters like haemoglobin with blood indices and iron prole was studied and compared in both groups. There was no signicant difference in the various parameters in both groups except a signicantly low MCH and MCHC and signicantly high ferritin levels in the diabetic group. We concluded that the low MCH and MCHC might be suggestive of an increased cardiovascular risk in diabetic patients while higher levels of serum ferritin may suggest sub-clinical inammation rather than iron overload. In conclusion diabetes remains to be the single most important aetiology for the causation of end stage renal disease and appropriate management of anaemia in terms of EPO and iron therapy remains the mainstay of therapy in haemodialyzed patients.