Abstract

A retrovirus-like element (TLev1) is located within the Tla locus of the C57BL/10 major histocompatibility complex (1). Low copy probes have been isolated from sequences flanking the TLev1 integration site to examine the distribution of TLev1 among inbred mouse strains having genotypically determined variations in TL antigen expression. Table 1 shows that the TLevl genome was present in 20 out of 20 mouse strains of the Tla b, nonexpressing (TL—), haplotype. Inbred strains of Tla a,c,e, expressing (TL+), haplotypes were not found to contain the TLev1 locus. Certain TL+ strains, including 3 Tla f inbred strains and an H-2 congenic strain, A.CA (Tla d), were found to contain TLev1 genomes indicating that the retrovirus does not exclusively correlate with the TL− phenotype.

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