Abstract
Objective To study the effects of aloe-emodin on apoptotic of systemic scleroderma skin fibroblasts. Methods Different concentration of aloe-emodin was used to treat the cultured fibroblasts. The effects of aloe-emodin on apoptosis in systemic scleroderma Skin Fibroblasts were detected by TUNEL and fluorescent microscope. Results The results showed that aloe-emodin induced the apoptotic of fibroblasts, and the tendency of apoptotie was increased along with time and the concentration of the drug. Conclusion Aloe-emodin induced the apoptotic of systemic scleroderma skin fibroblasts and could significantly inhibit the proliferation and collagen synthesis in cultured fibroblasts. Key words: ALOE-EMODIN/PD; Scleroderma; systemic/ZD ; Fibroblasts/DE ; Apoptosis
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