Study of adverse events reported to the center of health surveillance related to the use of intravenous immunoglobulin (IVIG)

Abstract

Event Abstract Back to Event Study of adverse events reported to the center of health surveillance related to the use of intravenous immunoglobulin (IVIG) Ida C. Gubert1*, Marcia Marques De Azevedo Dos Santos2 and Vera C. Zanetti2 1 UNIVERSIDADE FEDERAL DO PARANA, Brazil 2 Secretaria de Estado da Saude, Brazil Antibody replacement therapy was first introduced for clinical use in the 1950s mainly for the treatment of primary immunodeficiency conditions, usually used subcutaneously or intramuscularly, either as an adjunctive or first line therapy. Due to the recognition of its modulator effects, subsequently suitable preparations for intravenous use have been developed. Intravenous immunoglobulin has been, since then, increasingly used in many inflammatory and autoimmune conditions, although only a few have received approval by FDA and EMEA and unlabeled use is now common. Clinical preparations consist of IgG antibodies and all four subclasses, obtained from a pool of thousands of healthy donors, comprising the entire repertoire of antigen binding sites expectedly found in normal human serum. Intravenous immunoglobulin mechanisms of action are complex and include anti-infective, immunoregulatory, and anti-inflammatory properties. However, adverse events due to the use of this immunobiological have been reported. It is the purpose of this study to identify the adverse events most commonly reported to the center of health surveillance related to the use of intravenous immunoglobulin. Notification forms, spreadsheets and database files have been analyzed and data were organized and systematized in order to provide easy access to the information for health professionals and surveillance center. Hypersensitivity reactions, thrombotic events, acute renal failure and aseptic meningitis syndrome, chills, fever during infusion, artralgia, mialgia, abdominal pain and headache are some of the adverse events commonly reported. High cost, supplies and safety of the product are some of the concerns related to the use of intravenous immunoglobulin. Keywords: Immunotherapy, immunodeficiency, immunoglubulin, intravenous, adverse events Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Gubert IC, Marques De Azevedo Dos Santos M and Zanetti VC (2013). Study of adverse events reported to the center of health surveillance related to the use of intravenous immunoglobulin (IVIG). Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00383 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Ida C Gubert, UNIVERSIDADE FEDERAL DO PARANA, CURITIBA, Brazil, gubert@ufpr.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ida C Gubert Marcia Marques De Azevedo Dos Santos Vera C Zanetti Google Ida C Gubert Marcia Marques De Azevedo Dos Santos Vera C Zanetti Google Scholar Ida C Gubert Marcia Marques De Azevedo Dos Santos Vera C Zanetti PubMed Ida C Gubert Marcia Marques De Azevedo Dos Santos Vera C Zanetti Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.