Study of Activated Cellular Immunity due exposition to Systemic Endotoxinemia by Physical Exertion of Athletes

Abstract

Background: According to the study, the indices of cellular antiendotoxin immunity can be applied to assess the athletes’ adaptation to physical exertion at various stages of a one-year training program. In the early 90s of the 20th century, a new theory appeared about the role of endotoxin (ET) of intestinal microflora in physiology and human pathology, which, in our opinion, can be used to systematize knowledge about the development mechanisms of a general adaptation syndrome and form the basis of the general theory of its pathogenesis. Aim of the study: The study aims was to study the role of systemic endotoxinemia and indicators of cellular immunity in athletes of various sports specialization in assessing adaptation to physical activity. The article shows the possibility of using indicators of the cellular link of antiendotoxin immunity for assessment of the adaptation of the body of athletes to physical activity at different stages of the annual training cycle. Methodology: A study of the content of ET in the bloodstream and indicators of the granulocyte link was carried out to estimate antiendotoxin immunity for various athletes. Results: The results obtained show that trained and untrained people have a clearly expressed endotoxinemia, and the indicators of endotoxinemia significantly increase during exercise in the control group and among athletes. Conclusion: Our findings allow us to draw a conclusion about the very likely participation of ET in the development of pathological processes when adapting to physical activity. Recommendations: Make other studies among different athletes to analyze the relation and adaptation between immunity and endotoxins.