Abstract
The acid–base equilibria of fleroxacin were studied by means of potentiometry and spectrophotometry. It was established that fleroxacin undergoes a complex acid-base equilibrium due to its zwitterionic nature and two proton-binding sites of similar acidity. The stoichiometric equilibrium constants were determined at 25°C and constant ionic strength 0.1 M (NaCl). The acidity constants p K 1=5.59±0.01 and p K 2=8.08±0.04 were found by potentiometry, and p K 1=5.61±0.03 and p K 2=8.11±0.06 by spectrophotometry. The distribution diagram of the corresponding ionic species is given.
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