Abstract
Aerosols from the mainstream cigarette smoke have been analyzed by electrospray ionization (ESI) coupled to Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS). Measurements have been conducted in positive ion mode. The chemical composition of cigarette smoke aerosol is significant because it gives insights of one complex indoor environmental mixture. Almost 1300 chemical compositions relative to nitrogen species were successfully determined through the accurate mass measurement and the good ion production of the used technique. The most abundant class of compounds corresponds to N2 one (hydrocarbons with two nitrogen atoms). For other classes, the van Krevelen diagrams ensured to define that other nitrogen and oxygen-nitrogen compounds adopted similar behavior in terms of unsaturation and alkylation range. The detailed composition of cigarette smoke aerosol provided a typical chemical fingerprint from the biomass pyrolysis with tobacco-specific compounds. We examined also the contribution of laser desorption ionization (LDI) technique coupled to FTICRMS for the acute analysis of cigarette smoke aerosol. While a part of the chemical composition were found similar to ESI results, LDI achieved a broader range of poly-aromatic compounds and highlight new class compounds as pure hydrocarbon and oxygen-containing species. The combination of ESI and LDI with high resolution mass spectrometry clearly increased significantly the coverage of the “whole composition” of environmental aerosols such as cigarette smoke aerosol.
Highlights
Risk assessment for environmental and human point of view is a challenge for complex mixture exposures
We examined the contribution of laser desorption ionization (LDI) technique coupled to Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) for the acute analysis of cigarette smoke aerosol
While a part of the chemical composition were found similar to electrospray ionization (ESI) results, LDI achieved a broader range of poly-aromatic compounds and highlight new class compounds as pure hydrocarbon and oxygen-containing species
Summary
Risk assessment for environmental and human point of view is a challenge for complex mixture exposures. The first barrier is linked to the chemical identification of such mixtures at the molecular level It is the case for the condensed matter generated by the combustion of fuel, biomass or waste which is released in outdoor and indoor environments. Their chemical composition is sparsely covered because of their huge chemical diversity and the restricted number of compounds identified by the commonly used targeted analytical approach. To address a full chemical characterization of a complex mixture, a non-targeted approach has to be considered Such strategy pushes the analytical techniques to their limits and high performance instruments have to be used. We develop an innovative approach to investigate complex mixture composition
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