Study of 92 cases of ovarian germ cell tumour at tertiary health care centre

Abstract

Introduction: Ovarian germ cell neoplasm represents approximately 25 to 30 percent of ovarian tumours, which significantly varies with respect to their clinical presentation, histology, and biology. The main aim of this study is to evaluate frequency, incidence and histopathologic pattern with respect to age, sex and clinical presentation of tumor. Materials and Methods: This work is a retrospective study of ovarian germ cell tumors carried out in department of pathology at tertiary health care center. All cases of germ cell tumors during the period from May 2008 to June 2018 were retrieved from the record files and analyzed. The tissues were routinely fixed with 10% formalin, and the slides were stained with hematoxylin and eosin stain and also with special stains whenever required. Results: Out of 142 cases of GCTs, 15 cases (16.30%) ovarian GCT belonged to pediatric age group and 77 cases (83.69%) belonged to the adult age group (20-50Years). Out of 92 cases of ovarian neoplasm, most common histological types were mature teratoma 81.52%, followed by dysgerminoma 7.6%, immature teratoma 4 cases (4.34%) and mixed GCT 3.26%. There were 2 cases of yolk sac tumor and one case of choriocarcinoma. Abdominal pain followed by lump was the commonest Clinical presentation. Conclusion: Mature teratoma is the most common germ cell tumor, most commonly occurring in the 3rd decade. Dysgerminoma is the most common malignant germ cell tumor occurring in the 10-20 years age group. Keywords: Teratoma, Dysgerminoma, Ovary, Germ cell, Yolk sac tumour.