Abstract

Objective To improve the diagnosis and treatment of chromophobe renal cell carcinoma (CRCC),we investigated and summarized the clinical and pathological features of CRCC patients in our hospital.Methods We have retrospectively analyzed the clinical features of 33 CRCC patients.The mean age of these patients at diagnosis was 55 years-old,including 13 males and 20 females.All tumors were localized unilaterally,with 18 in left kidney and 15 in right kidney.Ultrasonography was performed on all patients,CT scan on 30 patients and MRI on 3 patients.Results All of the patients underwent surgery.Fifteen patients underwent radical nephrectomy,11 patients underwent laparoscopic radical nephrectomy,5 patients underwent nephron sparing surgery and 2 patients underwent laparoscopic nephron sparing surgery.The average diameter of tumors was 5.2 cm.Among them,23 patients were at pT1N0M0,6 at pT2N0M0,2 at T3N0M0 and 2 at T3N0M0.The pathologic Fuhrman grade of CRCC was G1 in 1 case,G2 in 19 cases,G3 in 9 cases and G4 in 4 cases.Twenty-six patients were followed up with a mean duration of 24 months and no local recurrence was found.Conclusions CRCC is a rare subtype of renal cell carcinoma with little recurrence and metastasis.Surgery was the common treatment for CRCC.Usually,CRCC patients have favorable prognosis. Key words: Carcinoma, renal cell; Chromophobe cell carcinoma; Diagnosis; Treatment; Prognosis

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