Study of 14-Substituted-14H-Dibenzo[a,j] Xanthene Derivatives

Abstract

Xanthene derivatives of the 14-aryl-14H dibenzo[a.j] xanthene type were exploited in our study because of their interesting biological profile as well as their innumerable applications described in previous studies. They were synthesized by one-pot condensation of [Formula: see text]-naphthol with arylaldehydes and catalyzed by zinc trifluoromethanesulfate Zn(OTf)2 under conventional heating without solvent. Their characterization was carried out by Ultraviolet–Visible spectrophotometry (UV–Vis), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). First, spectral analysis in the UV–Vis range showed that all xanthene derivatives had similar absorption spectra at an absorption maximum [Formula: see text] in the region of 310–340[Formula: see text]nm. Similarly, the infrared spectra suggested the presence of characteristic bands for each product in the range of 500–3500[Formula: see text]cm[Formula: see text]. In addition, the analysis of their crystalline structures was carried out by the XRD technique and reported in our study. Finally, their sizes and morphologies were highlighted by SEM. The obtained results revealed the presence of microcrystals in the form of micro-cubes having an average length of 10[Formula: see text][Formula: see text]m for the compound C[Formula: see text]H[Formula: see text]O and micro-shuttles of average size of 20[Formula: see text][Formula: see text]m for the compound C[Formula: see text]H[Formula: see text]BrO. It was therefore concluded that the xanthene derivatives synthesized have characteristic functional groups and structures which will provide them with various therapeutic properties and can therefore be exploited as bioactive molecules in several fields.