Study of 13C–19F and 1H–19F couplings in some fluorinated aromatic compounds using two‐dimensional 13C–1H chemical shift correlation spectroscopy with proton homonuclear decoupling

Abstract

AbstractThe magnitudes and relative signs of 13C–19F and 1H–19F coupling constants in 6‐F‐indole, 5‐ and 6‐F‐tryptamine, 5‐F‐indole‐3‐carboxaldehyde, 2‐ and 4‐F‐biphenyl, droperidol, flusperilene, 1‐F‐naphthalene and 3‐F‐fluroanthene (F = fluoro) have been determined using two‐dimensional 13C–1H chemical shift correlation spectroscopy with proton homonuclear decoupling. Except for one long‐range 1H–19F coupling constant, all the other observed 1H–19F couplings in these compounds were found to be of the same sign as the corresponding 13C–19F coupling constants. The variation of the magnitude of tlfe coupling constants due to substitution is relatively insignificant.