Abstract
<i>Toxoplasma.gondii </i>is a protozoan eukaryotic parasite that can enter the body host as an obligate intracellular parasite and causes toxoplasmosis infection, it has the ability to cause latent infection in the host tissue such as cardiac muscle, skeletal muscles, or the central nervous system Aim of study: Determine the relationship between the parasitic infection of <i>T. gondii</i> and Programmed cell death-1 (PD-1), TGF- ß and IL-10 during abortion. <i>Materials/Methods: </i>One hundred consecutive samples after abortion were collected. The placental tissue samples were put in formalin for immunohistochemistry technique. <i>Result t</i>he result of this study reveals that Residence did not have a relation with the presence or absence of Toxoplasmosis (P>0.05), age was significantly different between Toxoplasmosis groups (P<0.05), Number of abortions was not significantly different between the Toxoplasmosis group (P>0.05), PDL-1, IL-10, and TGF-β levels and their relationship during infection is significant (P<0.05). Conclusion the PDL-1, IL-10, and TGF-β levels could be a candidate as a biomarker for the pathological effect of <i>Toxoplasma.gondiin</i> during pregnancy.
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